Violation

Which of the following pharmacokinetic change(s) occur(s) with aging? 1. Absorption is altered by a decrease in the gastric pH. 2. Metabolism is decreased by a reduced liver mass. 3. Distribution is altered by a decrease in total body fat. 4. Excretion is reduced because of lessened renal blood flow.

(2) and (4)

(1) (2) (3)

(1) and (3)

(4) only

All of the above.

Please describe the matter of abuse