An anaphylactic reaction to penicillin is most likely to occur
1. when the drug is administered parenterally.
2. in patients who have already experienced an allergic reaction to the drug.
3. within minutes after drug administration.
4. when the drug is administered orally.

(1) (2) (3)

All of the above.

(4) only

(2) and (4)

(1) and (3)